PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia

The rare vaccine-induced immune thrombotic thrombocytopenia that may follow adenovirus-based Covid-19 vaccination resembles heparin-induced thrombocytopenia, but rapid assays for anti-PF4 antibodies used to diagnose HIT may be negative in patients with VITT. The PF4–serotonin release assay appears t...

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Bibliographic Details
Published in:New England Journal of Medicine 2021-07
Main Authors: Vayne, Caroline, Rollin, Jérôme, Gruel, Yves, Pouplard, Claire, Galinat, Hubert, Huet, Olivier, Mémier, Vincent, Geeraerts, Thomas, Marlu, Raphael, Pernod, Gilles, Mourey, Guillaume, Fournel, Alexandra, Cordonnier, Charlotte, Susen, Sophie
Format: Article
Language:English
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Summary:The rare vaccine-induced immune thrombotic thrombocytopenia that may follow adenovirus-based Covid-19 vaccination resembles heparin-induced thrombocytopenia, but rapid assays for anti-PF4 antibodies used to diagnose HIT may be negative in patients with VITT. The PF4–serotonin release assay appears to detect the IgG antibodies to PF4–PVS that mediate this condition.
DOI:10.1056/NEJMc2106383