In silico modeling gas molecules transfer through the biomembrane by kinks-solitons

It is shown that the mechanism of the gas molecules transfer through the lipid bilayer can be connected with the kink-solitons. They are appeared in the lipid bilayer as a result of structural changes in biomembranes. The analytical model describing the behavior of kink-solitons in the finite hydroc...

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Bibliographic Details
Main Authors: Mokrushnikov, P. V., Lezhnev, E. V., Rudyak, V. Ya
Format: Conference Proceeding
Language:English
Subjects:
Erythrocytes
Hydrocarbons
Lipids
Mathematical models
Molecular chains
Solitary waves
Stress distribution
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Summary:It is shown that the mechanism of the gas molecules transfer through the lipid bilayer can be connected with the kink-solitons. They are appeared in the lipid bilayer as a result of structural changes in biomembranes. The analytical model describing the behavior of kink-solitons in the finite hydrocarbon chain is presented. The kink-solitons are formed during the folding of the erythrocyte as it moves along the microcapillaries. The equation of the kink-soliton motion is derived. This equation is numerically solved. It is shown that kink-solitons can appear in both saturated and unsaturated alkyl chains. In unsaturated chains, the soliton is “smeared out,” CH2−groups vibrate around C=C bonds with a significant amplitude, taking away part of the soliton’s energy. The transport of gas molecules by kink-solitons in unsaturated chains is hindered in comparison with saturated hydrocarbon chains. When the mechanical stress field changes, a sharp change in membrane permeability occurs.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0053082