Reorganization of Self‐Assembled DNA‐Based Polymers using Orthogonally Addressable Building Blocks

Nature uses non‐covalent interactions to achieve structural dynamic reconfiguration of biopolymers. Taking advantage of the programmability of DNA/DNA interactions we report here the rational design of orthogonal DNA‐based addressable tiles that self‐assemble into polymer‐like structures that can be...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2021-06, Vol.60 (23), p.12911-12917
Main Authors: Gentile, Serena, Del Grosso, Erica, Prins, Leonard J., Ricci, Francesco
Format: Article
Language:English
Subjects:
Biopolymers
Deoxyribonucleic acid
DNA
DNA nanostructures
DNA nanotechnology
Monomers
Polymers
Reconfiguration
self-assembly
Supramolecular polymers
Tiles
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Summary:Nature uses non‐covalent interactions to achieve structural dynamic reconfiguration of biopolymers. Taking advantage of the programmability of DNA/DNA interactions we report here the rational design of orthogonal DNA‐based addressable tiles that self‐assemble into polymer‐like structures that can be reconfigured by external inputs. The different tiles share the same sticky ends responsible for self‐assembly but are rationally designed to contain a specific regulator‐binding domain that can be orthogonally targeted by different DNA regulator strands. We show that by sequentially adding specific inputs it is possible to re‐organize the formed structures to display well‐defined distributions: homopolymers, random and block structures. The versatility of the systems presented in this study shows the ease with which DNA‐based addressable monomers can be designed to create reconfigurable micron‐scale DNA structures offering a new approach to the growing field of supramolecular polymers. We report the rational design of orthogonal DNA‐based addressable tiles that can re‐organize in a dynamic and reversible way to display well‐defined distributions: homopolymers made of a single tile, random polymers in which different tiles are distributed randomly and block structures in which the tiles are organized in segments.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202101378