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An Intelligent Transdermal Formulation of ALA‐Loaded Copolymer Thermogel with Spontaneous Asymmetry by Using Temperature‐Induced Sol–Gel Transition and Gel–Sol (Suspension) Transition on Different Sides

Aqueous solutions of some amphiphilic block copolymers undergo a sol–gel transition upon heating and are thus called thermogels. In the thermogel family, some systems also exhibit a gel–sol (suspension) transition at higher temperatures following the sol–gel transition, which is usually ignored in b...

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Bibliographic Details
Published in:Advanced functional materials 2021-05, Vol.31 (22), p.n/a
Main Authors: Cao, Dinglingge, Chen, Xi, Cao, Feng, Guo, Wen, Tang, Jingyu, Cai, Caiyun, Cui, Shuquan, Yang, Xiaowei, Yu, Lin, Su, Yong, Ding, Jiandong
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Language:English
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Summary:Aqueous solutions of some amphiphilic block copolymers undergo a sol–gel transition upon heating and are thus called thermogels. In the thermogel family, some systems also exhibit a gel–sol (suspension) transition at higher temperatures following the sol–gel transition, which is usually ignored in biomedical applications. Herein, for the first time, a case is reported employing both the sol–gel transition and the gel–sol (suspension) transition, which is found in the development of a transdermal hydrogel formulation containing 5‐aminolevulinic acid for photodynamic therapy (PDT) of skin disease. Two poly(d,l‐lactide‐co‐glycolide)‐b‐poly(ethylene glycol)‐b‐poly(d,l‐lactide‐co‐glycolide) triblock copolymers of different block lengths are synthesized. The transition temperatures of the formulation can be easily adjusted to meet the condition of sol–gel transition temperature (Tgel) < room temperature (Tair) < gel–sol (suspension) temperature (Tsol (suspension)) < body temperature (Tbody) via changing the blending ratio. Therefore, after applying to skin, formulation of spontaneous asymmetry with a hydrogel outside and a sol (suspension) inside can avoid free flowing and achieve rapid release to ensure an efficient PDT. This study demonstrates such a concept via characterizations of the “block blend” biomaterials and drug release profiles, and also via cell experiments, in vitro permeation, and in vivo transdermal delivery studies. A concept of intelligent hydrogel employing both sol‐gel transition and gel‐sol(suspension) transition upon heating is put forward. This formulation with a hydrogel outside and a sol(suspension) inside is invented by meeting the condition of sol‐gel transition temperature (Tgel) < room temperature (Tair) < gel‐sol(suspension) temperature (Tsol (suspension)) < body temperature (Tbody), which can avoid free flowing and achieve rapid release.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202100349