Antioxidant, Antigenotoxic, and Hepatic Ameliorative Effects of Quercetin/Zinc Complex on Cadmium-Induced Hepatotoxicity and Alterations in Hepatic Tissue Structure

Applications of medicinal uses of metals and their complexes have been gaining major clinical significance, especially during the COVID-19 pandemic. The ligation behavior of quercetin (Q), a flavonoid, and Zn metal, i.e., the Zn/Q complex, was fully characterized based on molar conductance, infrared...

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Published in:Coatings (Basel) 2021-05, Vol.11 (5), p.501
Main Authors: Refat, Moamen S., Hamza, Reham Z., A. Adam, Abdel Majid, Saad, Hosam A., Gobouri, Adil A., Azab, Ehab, Al-Salmi, Fawziah A., Altalhi, Tariq A., Khojah, Ebtihal, Gaber, Ahmed, El-Megharbel, Samy M.
Format: Article
Language:English
Subjects:
Antioxidants
Cadmium
Cadmium chloride
Chemical analysis
Chemicals
Coordination compounds
Electronic spectra
Enzymes
Free radicals
Gene expression
Genotoxicity
Histology
Infrared analysis
Infrared spectra
Liver
NMR
Nuclear magnetic resonance
Oxidative stress
Proteins
Resistance
Statistical analysis
Thermogravimetric analysis
Toxicity
Transmission electron microscopy
Zinc compounds
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Summary:Applications of medicinal uses of metals and their complexes have been gaining major clinical significance, especially during the COVID-19 pandemic. The ligation behavior of quercetin (Q), a flavonoid, and Zn metal, i.e., the Zn/Q complex, was fully characterized based on molar conductance, infrared (IR) spectra, elemental analysis, electronic spectra, thermogravimetric analysis, proton nuclear magnetic resonance (1H-NMR), and transmission electron microscopy (TEM) in our lab. Hepatotoxicity was induced by cadmium (CdCl2). A total of 40 male albino rats were randomly distributed into the following four groups: Control, hepatotoxic group (CdCl2), Zn/Q-treated group, and group treated with a combination of CdCl2 and Zn/Q. Serum hepatic enzymes (AST, ALT, and LDH), total protein, and enzymatic and nonenzymatic antioxidant levels were determined. Histology and TEM for hepatic tissues, in addition to the gene expression of SOD as an antioxidant enzyme in the hepatic tissues, were evaluated. The Q/Zn treatment demonstrated potent protective effects against CdCl2-induced sever oxidative stress and suppressed hepatic toxicity, genotoxicity, liver enzyme disturbances, and structural alterations. In conclusion, the Zn/Q complex produced a high potent antioxidant effect against the oxidative injury and genotoxicity induced by CdCl2 and could be considered to be a potent ameliorative hepatoprotective agent against CdCl2 hepatotoxicity, which could be beneficial during the COVID-19 pandemic.
ISSN:2079-6412
2079-6412
DOI:10.3390/coatings11050501