Therapeutic results in three cases of ganglioneuroblastoma associated with opsoclonus myoclonus ataxia syndrome

There were four courses of chemotherapy for intermediate risk neuroblastoma, followed by partial excision of the tumor three more chemotherapy courses, a second non-radical operation, four courses of post-operative chemotherapy, primary tumor irradiation, and per-oral maintenance treatment with cis-...

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Bibliographic Details
Published in:Indian journal of cancer 2020-04, Vol.57 (2), p.216-218
Main Authors: Shtarbanov, Ivan, Boronsuzov, Ivan, Chakarov, Ivan, Konstantinov, Dobrin
Format: Article
Language:English
Subjects:
Acids
Ataxia
Chemotherapy
Childhood
Cognitive disorders
Eye movements
Fasciculation
Gait
Head injuries
Medical imaging
Medical prognosis
Myoclonus
Neuroblastoma
Neuroectodermal tumors
Neuromuscular diseases
Patients
Urine
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Summary:There were four courses of chemotherapy for intermediate risk neuroblastoma, followed by partial excision of the tumor three more chemotherapy courses, a second non-radical operation, four courses of post-operative chemotherapy, primary tumor irradiation, and per-oral maintenance treatment with cis-retinoic acid. [5] The main diagnostic criteria for OMA syndrome are:[6] Opsoclonus-fast, involuntary, arrhythmic eye movements in multiple directions (vertical, horizontal, torsional)Presence of myoclonus or ataxiaBehavioral changes (most often irritability) or sleep disturbances andDiagnosed neuroblastoma is detected in 50% of cases of OMA in childhood. [8] From a genetic perspective, neuroblastoma associated with OMA is characterized by low frequency of amplification of the MYCN gene, and in a significant percentage of cases, segmental chromosomal abnormalities, which also have an unfavorable prognostic value, are detected.
ISSN:0019-509X
1998-4774
DOI:10.4103/ijc.IJC_115_19