A Case of Possible IgG4-Related Disease with Bilateral Optic Neuropathy and Bilateral Hippocampal Bleed

IgG4-related disease (IgG4-RD) is a multisystem inflammatory disorder. The diagnosis requires consideration of clinical, radiographic, serological, and pathological evidence. Neurological involvement by IgG4-RD is relatively uncommon and is being increasingly recognized and reported with hypertrophi...

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Bibliographic Details
Published in:Neurology India 2021-03, Vol.69 (2), p.484-486
Main Authors: Gogineni, Sujana, Mehta, Anish, Shah, Arjun, Kumar, Selva, Nagappa, H, Pradeep, R, Javali, Mahendra, Acharya, Puroshottam, Srinivasa, Rangasetty
Format: Article
Language:English
Subjects:
Brain
Case studies
Diagnosis
Health aspects
Hemorrhage
Immunoglobulin G
Immunologic diseases
Risk factors
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Summary:IgG4-related disease (IgG4-RD) is a multisystem inflammatory disorder. The diagnosis requires consideration of clinical, radiographic, serological, and pathological evidence. Neurological involvement by IgG4-RD is relatively uncommon and is being increasingly recognized and reported with hypertrophic pachymeningitis and hypophysitis as the most frequent manifestations. IgG4-related involvement of brain parenchyma is rare, but isolated case reports exist. Here, we report a case of a young boy who presented to us with bilateral optic neuropathy and bilateral hippocampal bleed-related neurological involvement in a possible IgG4-RD, a rare entity.
ISSN:0028-3886
1998-4022
DOI:10.4103/0028-3886.314517