Prenatal stress perturbs fetal iron homeostasis in a sex-specific manner

What is the influence of chronic maternal prenatal stress (PS) on fetal iron homeostasis? In a prospective case-control study in 164 pregnant women, we show that cord blood transferrin saturation is lower in male stressed neonates. The total effect of PS exposure on fetal ferritin revealed a decreas...

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Bibliographic Details
Published in:arXiv.org 2021-12
Main Authors: Zimmermann, Peter, Antonelli, Marta C, Sharma, Ritika, Müller, Alexander, Zelgert, Camilla, Fabre, Bibiana, Wenzel, Natasha, Wu, Hau-Tieng, Frasch, Martin G, Lobmaier, Silvia M
Format: Article
Language:English
Subjects:
Electrocardiography
Ferritin
Fetuses
Gestation
Homeostasis
Iron
Transferrin
Online Access:Get full text
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Summary:What is the influence of chronic maternal prenatal stress (PS) on fetal iron homeostasis? In a prospective case-control study in 164 pregnant women, we show that cord blood transferrin saturation is lower in male stressed neonates. The total effect of PS exposure on fetal ferritin revealed a decrease of 15.4% compared with controls. Electrocardiogram-based Fetal Stress Index (FSI) identified affected fetuses non-invasively during the third trimester of gestation. FSI-based timely detection of fetuses affected by PS can support early individualized iron supplementation and neurodevelopmental follow-up to prevent long-term sequelae due to PS-exacerbated impairment of the iron homeostasis.
ISSN:2331-8422
DOI:10.48550/arxiv.2105.12809