Analytical method development and validation of teneligliptin by UV spectroscopy

Teneligliptin is a Dipeptidyl peptidase-4 (DPP-4) inhibitor that has lately appeared as a new antidiabetic class that shows positive outcomes in improved glycaemic control.DPP-4 inhibitors boost effective GLP1 1 Peptide 1 Hormone) and GIP (Glucosedependent insulin tropic peptide) concentrations by i...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2021, Vol.14 (1), p.75-78
Main Authors: Maruthi, R, Chandan, R.S., Barath, M, Datta, G Naveen, D'silva, Merryl, Kumari, Kajal M, Ahmad, Farhan, Geetha, R
Format: Article
Language:English
Subjects:
Analytical chemistry
Calibration
Conflicts of interest
Diabetes
Drug dosages
Methods
Peptides
Pharmaceuticals
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Summary:Teneligliptin is a Dipeptidyl peptidase-4 (DPP-4) inhibitor that has lately appeared as a new antidiabetic class that shows positive outcomes in improved glycaemic control.DPP-4 inhibitors boost effective GLP1 1 Peptide 1 Hormone) and GIP (Glucosedependent insulin tropic peptide) concentrations by inhibiting DPP-4 enzymatic activity, thus improving glucose-dependent hyperglycemia in patients with diabetes by raising serum insulin levels and lowering serum glucagon levels. Absorption was estimated at 246nm, and percent recovery results were reported Precision: Excelling replicability with the present relative standard deviation (RSD percentage) under 2.0 percent was the precision (intra-day measurements, interday, repetitiveness) results. Development and validation of UV spectrophotometric method and high-performance thin-layer chromatographic (HPTLC) method for estimation of teneligliptin hydrobromide in pharmaceutical preparation.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2021.00014.7