The association between Angiopoietin-2 and the risk of recurrent implantation failure

Objectives: to assess the possible association between Angiopoietin-2 (ANGT-2) and the risk of recurrent implantation failure and to determine the possible role of it in the successfulness of in vitro fertilization process. Methods: A case control study was done on 80 female patients with Recurrent...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2021-04, Vol.14 (4), p.2031-2034
Main Authors: Abdulhaleem, Laith S, Abdul-Rasheed, Omar F, Abdullah Al-Awadi, Salwa J, Abdullah, Thuraya H
Format: Article
Language:English
Subjects:
Angiogenesis
Cell growth
Endometrium
Females
Gynecology
In vitro fertilization
Infertility
Kinases
Medical prognosis
Medical research
Obstetrics
Reproductive technologies
Variance analysis
Vascular endothelial growth factor
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Summary:Objectives: to assess the possible association between Angiopoietin-2 (ANGT-2) and the risk of recurrent implantation failure and to determine the possible role of it in the successfulness of in vitro fertilization process. Methods: A case control study was done on 80 female patients with Recurrent Implantation Failure (RIF) and 23 female patients with successful in-vitro fertilization (IVF) who were recruited from the Department of Obstetrics and Gynecology at Al Imamain Al-Kadhimain Medical City, Baghdad, Iraq between January and September 2019. The levels of ANGT-2 were measured in the serum of women with RIF and successful IVF and compared with those with a positive IVF and control group that comprise 74 age, BMI and sex-matched apparently healthy females. Results: The data revealed that there was a significant (p=0.007) decrease in ANGPT2 levels (2914.66±834.08) in women with recurrent implantation failure (RIF) in a comparison with controls (3235.83 ±444.16) whereas non-significant (p>0.05) differences were obtained between women with a successful in vitro fertilization (+ve IVF) and controls and also with RIF group. Conclusions: the possible association between ANGT-2 and the risk of RIF and the possibility of using it as a marker for a prognosis in women subjected to IVF process
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2021.00360