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Study on conditions for Gama buryric acid (GABA) production in Lactobacillus fermentum A01 isolated from human

Lactic acid bacteria play a vital role in biosynthesis of γ -aminobutyric acid (GABA) in the presence of glutamic acid - major substrate for the process. In recent study, Lactobacillus fermentum A01 (L. fermentum A01) isolated from various sources in Vietnam were screened for bacteria strains with h...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2021-04, Vol.14 (4), p.2188-2190
Main Authors: Thien Phuc, Cat, Thanh Vinh, Doan Thi, Khoa My, Truong, Thu Hien, Tran Thi, Anh Dung, Nguyen, Minh Thu, Tran Thi, Khue Nguyen, Tu Hoang
Format: Article
Language:English
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Summary:Lactic acid bacteria play a vital role in biosynthesis of γ -aminobutyric acid (GABA) in the presence of glutamic acid - major substrate for the process. In recent study, Lactobacillus fermentum A01 (L. fermentum A01) isolated from various sources in Vietnam were screened for bacteria strains with high efficiency in GABA formation. L. fermentum was cultured in MRS broth containing 25 mg/mL monosodium glutamate (MSG), at pH of 6.5 and incubated at the optimal conditions (37ºC, for 24, 48, 72 h). After extraction and thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) analysis, L. fermentum A01 showed the GABA yield about 1.34 mg/g in dried supernatant, suggesting L. fermentum A01 to be a promising GABA producer for food and pharmaceutical applications.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2021.00387