In-vitro Screening for Cytotoxic Activity of Herbal Plant Extracts on N2a Cell Lines

Clitoria ternatea, Cucurbita maxima, Artemisia vulgaris were the Indian native plants used in the treatment of different diseases. The methanolic extract of Clitoria ternatea, petroleum ether extract of Cucurbita maxima and methanolic extract of Artemisia vulgaris were investigated using MTT (3-(4,5...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2021-04, Vol.14 (4), p.2009-2012
Main Authors: G, Neelamma, Harun Rasheed, Shaik, Vinukonda, Anjaneyulu, M, Aruna
Format: Article
Language:English
Subjects:
Ayurvedic medicine
Cancer therapies
Cytotoxicity
Drugs
Herbal medicine
Herbs
Natural products
Neuroblastoma
Pharmaceutical industry
Phytochemicals
Seeds
Tumors
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Summary:Clitoria ternatea, Cucurbita maxima, Artemisia vulgaris were the Indian native plants used in the treatment of different diseases. The methanolic extract of Clitoria ternatea, petroleum ether extract of Cucurbita maxima and methanolic extract of Artemisia vulgaris were investigated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. These extracts were assessed using N2a cell line (Neuroblastoma). Cisplatin was used as a positive control based on IC50 values. Artemisia vulgaris methanol extract have highest cytotoxicity (80.81ug/mL) and Cucurbita maxima seed extract have lowest cytotoxicity (57.655ug/mL). The comparison of IC50 of the extracts had shown the following toxicity: Cucurbita maxima petroleum ether extract
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2021.00356