Liposome Mediated Pulmonary Drug Delivery System: An updated Review

Liposomal drug delivery systems have been widely used in pulmonary drug delivery for multiple applications which includes optimum solubilization of active pharmaceutical agents, prolonged period of drug release. [...]the site avoidance and site-specific drug targeting therapy could be achieved by th...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2021-03, Vol.14 (3), p.1791-1796
Main Authors: Paul, Susanta, Roy, Tathagata, Bose, Anannya, Chatterjee, Debasmita, Chowdhury, Victor Roy, Rana, Meghamouli, Das, Ashmita
Format: Article
Language:English
Subjects:
Aerosols
Cancer therapies
Drug delivery systems
Drug dosages
Hydration
Inhalers
Lipids
Lung cancer
Methods
Pharmaceuticals
Solvents
Tuberculosis
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Summary:Liposomal drug delivery systems have been widely used in pulmonary drug delivery for multiple applications which includes optimum solubilization of active pharmaceutical agents, prolonged period of drug release. [...]the site avoidance and site-specific drug targeting therapy could be achieved by the liposomal drug delivery system, to inhibit the tissue toxicity of many potent drug substances. The administration of drugs by the pulmonary route, particularly for drug targeting into the lung, provides promise for the treatment of a broad spectrum of pulmonary disorders like lung cancer, tuberculosis and offers numerous advantages over other conventional formulations.1,2 Lungs are an attractive target for the pulmonary drug delivery of active pharmaceutical ingredients in the form of various drug delivery approaches.3 Additionally, pulmonary route offers many systemic advantages over other conventional drug delivery systems, such as a high surface area with rapid absorption due to high vascularization and circumvention of the first pass effect.4 A majority of anti-tubercular drugs, which are highly effective towards the affected cells in the lung and it also, affect the normal cells. [...]the long duration of antitubercular therapy is related to various adverse effects and poor patient compliance. Dry powder formulations are used to improve this stability problem.11 Methods of Liposome Preparation: The conventional methods for preparing liposomes include dissolving the lipids in organic solvent, drying down the lipids from organic solutions to get a thin lipid film under vacuum, finally the dispersion of lipids film in aqueous media to form liposomal vesicles, purification of prepared liposomes and analysis of the final product.
ISSN:0974-3618
0974-306X
DOI:10.5958/0974-360X2021.00318.8