Formulation and evaluation of sertaconazole nitrate loaded nanosponges for topical application

Nanosponges loaded hydrogels were prepared by "Emulsion solvent diffusion method" using different polymers like ethyl cellulose and polymethyl methacrylate, a surfactant named polyvinyl alcohol and a crosslinking agent dichloromethane. The study concluded that sertaconazole nitrate loaded...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2021-02, Vol.14 (2), p.895-902
Main Authors: Harsha, G, Shaik, Naseeb Basha, Lakshmi, PK, Latha, K
Format: Article
Language:English
Subjects:
Antifungal agents
Cellulose
Design of experiments
Drug delivery systems
Drug dosages
Efficiency
Fourier transforms
Polymers
Polymethyl methacrylate
Polyvinyl alcohol
Potassium
Retention
Skin
Solvents
Surfactants
Variables
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Summary:Nanosponges loaded hydrogels were prepared by "Emulsion solvent diffusion method" using different polymers like ethyl cellulose and polymethyl methacrylate, a surfactant named polyvinyl alcohol and a crosslinking agent dichloromethane. The study concluded that sertaconazole nitrate loaded nanosponges have control release effect for prolonged period of time in the skin and it has been reported to show site targeted effect with reduced incidence of side effects and dosing frequency for the treatment of skin disorders like athelete's foot, dermatophytosis and candidiasis. Materials: Sertaconazole nitrate was obtained as a gift sample from varahi Pvt. Ltd., Ethyl cellulose from balaji drugs, Polymethylmathacrylate from research-lab fine chem industries, Polyvinyl alcohol from NR chem, dichloromethane from S.D fime chemicals Ltd., Methyl paraben from S.D fine chemicals Ltd., and Methanol from merck life sciences Pvt. Ltd. Experimental methodology: Optimization of sertaconazole nitrate loaded nanosponge gel using Taguchi OA L8 as design of experiment (DOE): Taguchi OA L8 experimental design was used to study the effect of different polymers like ethyl cellulose (EC), polymethyl methacrylate (PMMA) at two levels, effect of surfactant like polyvinyl alcohol at two levels of 0.2% and 0.3% and effect of crosslinking agent like dichloromethane at two levels of 10ml and 20ml.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2021.00159.1