The use of Urinary α-amylase level in a diagnosis of Chronic renal failure

• Published in: Research journal of pharmacy and technology 2021-03, Vol.14 (3), p.1597-1600
• Main Authors: Aldafaay, Ameer A A, Amir, Haidar A Abdul, Abdulhussain, Hiba A, Badry, Aurok S, Abdulsada, Ameer K
• Format: Article
• Language: English
• Subjects: Abdomen; Accuracy; Age; Creatinine; Cysts; Enzymes; Glucose; Kidney diseases; Pancreatitis; Plasma; Teaching hospitals; Urine
• ISSN: 0974-3618; 0974-306X
• DOI: 10.5958/0974-360X.2021.00283.3

[...]this method has drawbacks like the operating conditions are of highly acidic nature and high temperatures. a-Amylase presents at a high concentration in pancreatic juice and in saliva and may be extracted from other tissues, such as the gonads, Fallopian tubes, skeletal muscle and adipose tissue. In the absence of renal insufficiency, the urinary excretion remained always abnormal when the serum concentration was abnormal, and the excretion remained abnormal for 2 to 50 days even after the serum concentration had returned to normal. [...]the urinary amylase excretion is a useful monitor for the diagnosis of subsiding pancreatitis and for convalescent care of acute pancreatitis, such as the initiation of oral feeding, the enrichment of dietary components, the discontinuation of bed rest, and the start of exercise8-10. Newer and future techniques of determining renal function in patients with renal failure include determination of clearance of small doses (10 ml) of non-radioactive low osmolar contrast media (LOCM) (iohexol), dynamic MR imaging with gadolinium DTPA, and MR imaging with ultra-small particles of iron oxide (USPIO)17-23. [...]Berk et al., 1979 said that impaired renal function may be associated with rises in serum amylase activity and the ratio of amylase clearance to creatinine (Cam/Ccr) and this increase in the level of serum amylase may indicate the decrease in the amylase clearance by the kidney which is in agreement with results obtained in this study27.