Emergent strategy in management of inflammatory bowel disease: A narrowed in on novel drugs

• Published in: Research journal of pharmacy and technology 2021-03, Vol.14 (3), p.1811-1814
• Main Authors: Chandra, Srikanta, Das, Avik, Roy, Tathagata, Bose, Preeta, Paul, Susanta, Mukherjee, Lucky, Das, Arijit
• Format: Article
• Language: English
• Subjects: Crohn's disease; Epidemiology; Immune system; Inflammation; Inflammatory bowel disease; Microbiota; Pathogenesis; Pediatrics; Tumor necrosis factor-TNF
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2021.00321.8

According to American Gastrological Society (AGS) IBD is defined acute or chronic idiopathic ulceroinflammatory condition of the bowel which may or may not have transmural stretch. According to American Gastrological Society (AGS) IBD is defined as acute or chronic idiopathic ulceroinflammatory condition of the bowel which may or may not have transmural stretch. Inflammatory bowel disease (IBD) is a multifactorial disorder characterized by chronic inflammation of the intestine. Since the pivotal point is that disturbance of the immune system or imbalanced interactions with microbes leads to amelioration of chronic intestinal inflammation. Th1 cells play a role in the pathogenesis of Inflammatory bowel disease (IBD) is related to chrocity of intestinal inflammation where as Th2 cells play a role in the pathogenesis of Crohn's disease (CD) However, after activation of Th17 / regulatory T (Treg cells) are pivotal component which is helped to build up intestinal inflammation.8 Since, Tumor necrosis factor (TNF) are plays a instrumental role to identify the pathogenesis of Inflammatory bowel disease (IBD). [...]genetic factors plays a role so here mutation of NOD2 gene is a instrumental point in the pathogenesis of inflammatory bowel disease (IBD).9 The intestinal epithelium which is a pivotal part of the innate immune system and play a role in the maintenance of mucosal homeostasis.