Electrochemical Determination of Uric Acid in Urine by Using Zeolite Imidazolate Framework-11 Modified Electrode

• Published in: Journal of nanomaterials 2021, Vol.2021, p.1-13
• Main Authors: Thanh, Tran Si, Qui, Phan Tu, Tu, Nguyen Thi Thanh, Toan, Tran Thanh Tam, Hoa, Tran Thi Bich, Son, Le Van Thanh, Nguyen, Do Mai, Tuyen, Tran Ngoc, Khieu, Dinh Quang
• Format: Article
• Language: English
• Subjects: Adsorption; Anodic stripping; Anodizing; Buffer solutions; Carbon; Chromatography; Electrochemical analysis; Electrodes; Glassy carbon; Imidazole; Morphology; Nanomaterials; Nitrogen; Oxidation; Particle size; Phase transitions; Porous materials; Scanning electron microscopy; Solvents; Topology; Uric acid; Urine; Voltammetry; Zeolites; Zinc
• ISSN: 1687-4110; 1687-4129
• DOI: 10.1155/2021/9914062

In the present article, the synthesis of zeolite imidazole framework-11 (ZIF-11) by ultrasonic-assisted hydrothermal process and its application as an electrode modifier for electrochemical determination of uric acid in urine are demonstrated. The obtained materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and nitrogen adsorption/desorption isotherms. It was found that the ZIF-11 with rhombic dodecahedron topology and high surface area (1066 m2.g-1) was synthesized in a certain temperature and found in around 25–40°C, and other crystalline phases of zinc benzimidazolate deferring from ZIF-11 phase were found in less 25°C or higher than 40°C. The ZIF-11 is stable in the pH range 6-10. The modification of glassy carbon electrode was performed with ZIF-67 using the drop-casting procedure. The present ZIF-11 modified electrode was employed to study the electrochemical behavior of uric acid (UA). UA oxidation is catalyzed by this electrode in aqueous buffer solution (pH 7) with a decrease of 70 mV in overpotential compared to glassy carbon electrode. With the differential pulse–anodic stripping voltammetry (DP-ASV) method, the oxidation current of UA versus its concentration shows good linearity in the range 20–540μM (R=0.998) with a detection limit of 0.48 μM (S/N=3). The obtained ZIF-11 modified electrode was applied in the detection of UA content in urine samples, and satisfied results were obtained.