Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas

This paper reviews efforts across 16 international consortia to construct human anatomical structures, cell types, and biomarkers (ASCT+B) tables and three-dimensional reference organs in support of a Human Reference Atlas. We detail the ontological descriptions and spatial three-dimensional anatomi...

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Bibliographic Details
Published in:bioRxiv 2021-06
Main Authors: Borner, Katy, Teichmann, Sarah A, Quardokus, Ellen M, Gee, James, Browne, Kristen, Osumi-Sutherland, David, Herr, Bruce W, Bueckle, Andreas, Hrishikesh, Paul, Haniffa, Muzlifah A, Jardine, Laura, Bernard, Amy, Song-Lin, Ding, Miller, Jeremy A, Lin, Shin, Halushka, Marc, Boppana, Avinash, Longacre, Teri A, Hickey, John, Lin, Yiing, Valerius, M Todd, He, Yongqun, Pryhuber, Gloria, Sun, Xin, Jorgensen, Marda, Radtke, Andrea, Wasserfall, Clive, Ginty, Fiona, Ho, Jonhan, Sunshine, Joel, Beuschel, Rebecca T, Brusko, Maigan, Lee, Sujin, Malhotra, Rajeev, Jain, Sanjay, Weber, Griffin
Format: Article
Language:English
Subjects:
Biomarkers
Cell Biology
Interfaces
Medical research
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Summary:This paper reviews efforts across 16 international consortia to construct human anatomical structures, cell types, and biomarkers (ASCT+B) tables and three-dimensional reference organs in support of a Human Reference Atlas. We detail the ontological descriptions and spatial three-dimensional anatomical representations together with user interfaces that support the registration and exploration of human tissue data. Four use cases are presented to demonstrate the utility of ASCT+B tables for advancing biomedical research and improving health. Competing Interest Statement The authors have declared no competing interest.
ISSN:2692-8205
DOI:10.1101/2021.05.31.446440