(2-Fluoroallyl)pyridinium tetrafluoroborates: novel fluorinated electrophiles for Pd-catalyzed allylic substitution

An efficient two-step approach to 2-fluoroallyl amines was developed that involves the synthesis of (2-fluoroallyl)pyridinium tetrafluoroborates from readily available gem -bromofluorocyclopropanes and the application of the former as novel and stable 2-fluoroallyl electrophiles for Pd-catalyzed all...

Full description

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry 2021-06, Vol.19 (21), p.4678-4684
Main Authors: Bobrova, Angelina Yu, Novikov, Maxim A, Tomilov, Yury V
Format: Article
Language:English
Subjects:
Amines
NMR
Nuclear magnetic resonance
Palladium
Pyridinium
Substitutes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient two-step approach to 2-fluoroallyl amines was developed that involves the synthesis of (2-fluoroallyl)pyridinium tetrafluoroborates from readily available gem -bromofluorocyclopropanes and the application of the former as novel and stable 2-fluoroallyl electrophiles for Pd-catalyzed allylic substitution. An efficient two-step approach to 2-fluoroallyl amines was developed using (2-fluoroallyl)pyridinium tetrafluoroborates as novel fluorinated electrophiles for Pd-catalyzed allylic substitution.
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob00567g