New method for the synthesis of 4-spirocyclopentane- and 4-spirocyclohexanenicotinic acid nitriles and amides

The multicomponent condensation of cyclopentylidene- or cyclohexylidenemalononitrile, cyanoacetic acid amides or thioamides, and alkylating agents affords 4-spirocyclopentane- and 4-spirocyclohexanenicotinic acid nitriles and amides. The structures of several reaction products were determined by X-r...

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Bibliographic Details
Published in:Russian chemical bulletin 2021-05, Vol.70 (5), p.949-959
Main Authors: Dyachenko, I. V., Dyachenko, V. D., Dorovatovskii, P. V., Khrustalev, V. N., Nenajdenko, V. G.
Format: Article
Language:English
Subjects:
Alkylation
Amides
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Condensates
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Inorganic Chemistry
Nitriles
Organic Chemistry
Reaction products
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Summary:The multicomponent condensation of cyclopentylidene- or cyclohexylidenemalononitrile, cyanoacetic acid amides or thioamides, and alkylating agents affords 4-spirocyclopentane- and 4-spirocyclohexanenicotinic acid nitriles and amides. The structures of several reaction products were determined by X-ray diffraction.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-021-3172-9