Modified Hydrogel as a Carrier of Oral Insulin

The effect of the structure of a mucoadhesive, insulin-containing, polymeric hydrogel on the rate of hormone release was studied. It has been shown that a decrease in the pore size of the hydrogel leads to an increase in the rate of insulin release, which contributes to a reduction in the time to ac...

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Bibliographic Details
Published in:Applied biochemistry and microbiology 2021-05, Vol.57 (3), p.373-376
Main Authors: Valuev, L. I., Valuev, I. L., Vanchugova, L. V., Obydennova, I. V.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Hormone release
Hydrogels
Insulin
Life Sciences
Medical Microbiology
Microbiology
Oral administration
Physiological effects
Pore size
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Summary:The effect of the structure of a mucoadhesive, insulin-containing, polymeric hydrogel on the rate of hormone release was studied. It has been shown that a decrease in the pore size of the hydrogel leads to an increase in the rate of insulin release, which contributes to a reduction in the time to achieve a positive effect upon oral administration of the drug while maintaining the physiological pathway of hormone penetration of the blood through the liver.
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683821020186