A Cross- Sectional Study on Assessment of Hyperparathyroidism in Patients with End-Stage of Renal Failure

Serum creatinine,urea,uric acid ALP, calcium and blood electrolytes sodium and potassium were quantified , followed by statistical analysis and their correlation. The intact parathyroid hormone (iPTH MW~9425k Daltons) is an 84 amino acid polypeptide that increases serum calcium concentration by incr...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2021-05, Vol.13 (5), p.254-258
Main Authors: Usmani, Rana, Negi, Kanchan, Masood, Tariq, Kakkar, Kanika, Kamboj, Tanjum, Kushwaha, Rajeev Singh
Format: Article
Language:English
Subjects:
Age groups
Biochemistry
Creatinine
Cross-sectional studies
Diabetes
Estrogens
Females
Gender differences
Hospitals
Hypertension
Kidney diseases
Males
Metabolism
Nephrology
Phosphatase
Phosphorus
Statistical analysis
Uric acid
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Summary:Serum creatinine,urea,uric acid ALP, calcium and blood electrolytes sodium and potassium were quantified , followed by statistical analysis and their correlation. The intact parathyroid hormone (iPTH MW~9425k Daltons) is an 84 amino acid polypeptide that increases serum calcium concentration by increasing calcium reabsorption in the thick ascending loop of nephron, increasing activated vitamin D (calcitriol) [10], production and indirectly increasing bone reabsorption. Serum urea, Serum creatinine, Serum uric acid, Serum I PTH, Serum electrolyte were estimated in these patients.ESRD is associated with aberrations in the metabolism of minerals, such as calcium, phosphates, magnesium, sodium, and potassium. Kirti Arora et.al in 2018 found in their study of 60 patients that the mean age was 52.28±16.25years with male and female and the ratio between male and female was 1.5:1 [13].In our present study it was observed the value of serum iPTH is 645.62±468.8 pg/ml which was significantly higher in cases as compared to the control group.A previous study has suggested that elevation of PTH levels in patients with End-stage kidney disease increases cytoplasmic calcium concentration in vascular smooth muscle cells and thereby it promotes increases blood pressure.
ISSN:0975-1459