Nanotherapeutics using all-natural materials. Effective treatment of wound biofilm infections using crosslinked nanoemulsions

Bacterial wound infections are a threat to public health. Although antibiotics currently provide front-line treatments for bacterial infections, the development of drug resistance coupled with the defenses provided through biofilm formation render these infections difficult, if not impossible, to cu...

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Bibliographic Details
Published in:Materials horizons 2021-06, Vol.8 (6), p.1776-1782
Main Authors: Li, Cheng-Hsuan, Landis, Ryan F, Makabenta, Jessa Marie, Nabawy, Ahmed, Tronchet, Tiphaine, Archambault, Danielle, Liu, Yuanchang, Huang, Rui, Golan, Morgane, Cui, Wei, Mager, Jesse, Gupta, Akash, Schmidt-Malan, Suzannah, Patel, Robin, Rotello, Vincent M
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Bacterial infections
Bacterial Infections - drug therapy
Biodegradation
Biofilms
Drug resistance
Gelatin
Infections
Infrared spectroscopy
Mice
Nanoemulsions
Natural resources
Oregano
Public health
Riboflavin
Wound healing
Wound Infection - drug therapy
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Summary:Bacterial wound infections are a threat to public health. Although antibiotics currently provide front-line treatments for bacterial infections, the development of drug resistance coupled with the defenses provided through biofilm formation render these infections difficult, if not impossible, to cure. Antimicrobials from natural resources provide unique antimicrobial mechanisms and are generally recognized as safe and sustainable. Herein, an all-natural antimicrobial platform is reported. It is active against bacterial biofilms and accelerates healing of wound biofilm infections in vivo . This antimicrobial platform uses gelatin stabilized by photocrosslinking using riboflavin (vitamin B 2 ) as a photocatalyst, and carvacrol (the primary constituent of oregano oil) as the active antimicrobial. The engineered nanoemulsions demonstrate broad-spectrum antimicrobial activity towards drug-resistant bacterial biofilms and significantly expedite wound healing in an in vivo murine wound biofilm model. The antimicrobial activity, wound healing promotion, and biosafety of these nanoemulsions provide a readily translatable and sustainable strategy for managing wound infections. All-natural cross-linked nanoemulsions provide effective treatment of wound biofilm infections.
ISSN:2051-6347
2051-6355
DOI:10.1039/d0mh01826k