A simple polysaccharide based injectable hydrogel compositing nano-hydroxyapatite for bone tissue engineering

•A simple polysaccharide injectable hydrogel was prepared based on Schiff base crosslinking.•Nano-hydroxyapatite could be uniformly composited in the hydrogel.•The composite hydrogel showed excellent compact bone repair effect.•The bone repair mechanism meets the concept of Guided Bone Regeneration...

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Bibliographic Details
Published in:Materials letters 2021-06, Vol.293, p.129755, Article 129755
Main Authors: Cao, Zhen, Bai, Xiao, Wang, Chongbin, Ren, Liling, Ma, Dongyang
Format: Article
Language:English
Subjects:
Biocompatibility
Biomaterials
Biomedical materials
Bone repair
Bones
Chitosan
Composite materials
Crosslinking
Dextrans
Hydrogels
Hydroxyapatite
Imines
Injectable hydrogel
Materials science
Polysaccharides
Repair
Rheological properties
Scaffolds
Tissue engineering
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Summary:•A simple polysaccharide injectable hydrogel was prepared based on Schiff base crosslinking.•Nano-hydroxyapatite could be uniformly composited in the hydrogel.•The composite hydrogel showed excellent compact bone repair effect.•The bone repair mechanism meets the concept of Guided Bone Regeneration (GBR). The biomaterials based injectable hydrogel showed great potential as bone tissue engineering scaffold for its biocompatibility, injectable nature and interconnected porous structure that favors loading bioactive substances or cells for bone repair. In this study, N-carboxyethyl chitosan (NCEC) and oxidized dextran (ODex) was synthesized to fabricate a simple polysaccharide injectable hydrogel based on Schiff base crosslinking (dynamic imine bonds), to composite nano-hydroxyapatite (nHAP) for rat cranial bone repair. The polysaccharide hydrogel displayed interconnected porous structure and suitable rheological properties for compositing nHAP. Biochemical properties of the hydrogel were not affected through the composition of nHAP. In vivo cranial bone repair results showed excellent bone repair effect of the composite materials, demonstrating the simply constructed polysaccharide hydrogel is suitable as bone tissue engineering scaffold.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2021.129755