Chitosan based fibrous absorbents for indoxyl sulfate sorption

[Display omitted] •Non-physical equilibrium established between chitosan and indoxyl sulfate.•Biocompatible fibrous absorbent with smooth fibre surface.•Significant indoxyl sulfate absorption at low indoxyl sulfate level (5 mg/L) within 1 h in a single pass.•A programmable close-range electrospinnin...

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Bibliographic Details
Published in:Materials letters 2021-06, Vol.293, p.129744, Article 129744
Main Authors: Xiong, Siyu, Lyu, Yaxuan, Davenport, Andrew, Choy, Kwang Leong
Format: Article
Language:English
Subjects:
Absorbent
Absorbents
Chitosan
Clearances
Electrospinning
Fibrous materials
Materials science
Polycaprolactone
Proteins
Toxicity
Toxins
Ureamic toxin removal
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Summary:[Display omitted] •Non-physical equilibrium established between chitosan and indoxyl sulfate.•Biocompatible fibrous absorbent with smooth fibre surface.•Significant indoxyl sulfate absorption at low indoxyl sulfate level (5 mg/L) within 1 h in a single pass.•A programmable close-range electrospinning setup is used to fabricate the fibrous composite absorbent. Standard dialyzer membranes, designed for diffusive clearance, do not effectively clear protein-bound uremic toxins, such as indoxyl sulfate (IS). To increase protein-bound toxins removal, absorbents require a high specific surface area to achieve effective size-coupling removal of target toxins. However, the toxicity of a molecule is not necessarily determined by size alone. As proof of concept, we report on an electrospun polycaprolactone/chitosan (PCL/CS) fibrous absorbent for IS removal based on chemical structural interaction. A single unit (20 mm in length) of our PCL/CS absorbent achieved a 28% clearance of IS within an hour at both 40 mg/L and 5 mg/L concentrations in a single pass model. This fibrous absorbent structure offers new thoughts on absorbent design.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2021.129744