A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern

Background/Objectives Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome...

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Published in:European journal of clinical nutrition 2021-06, Vol.75 (6), p.937-945
Main Authors: Suzuki, Harumitsu, Nakamura, Yasuyuki, Matsuo, Keitaro, Imaeda, Nahomi, Goto, Chiho, Narita, Akira, Shimizu, Atsushi, Takashima, Naoyuki, Matsui, Kenji, Miura, Katsuyuki, Nakatochi, Masahiro, Hishida, Asahi, Tamura, Takashi, Kadomatsu, Yuka, Okada, Rieko, Nishida, Yuichiro, Shimanoe, Chisato, Nishimoto, Daisaku, Takezaki, Toshiro, Oze, Isao, Ito, Hidemi, Ikezaki, Hiroaki, Murata, Masayuki, Matsui, Daisuke, Ozaki, Etsuko, Mikami, Haruo, Nakamura, Yohko, Suzuki, Sadao, Watanabe, Miki, Arisawa, Kokichi, Uemura, Hirokazu, Kuriki, Kiyonori, Momozawa, Yukihide, Kubo, Michiaki, Kita, Yoshikuni, Takeuchi, Kenji, Wakai, Kenji
Format: Article
Language:English
Subjects:
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Cardiovascular diseases
Chromosome 14
Clinical Nutrition
Eating behavior
Energy intake
Environmental factors
Epidemiology
Food
Food groups
Food habits
Gene expression
Genes
Genetic aspects
Genetic diversity
Genetic factors
Genetic research
Genetic variation
Genome-wide association studies
Genomes
Histocompatibility
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Obesity
Olfaction
Pattern analysis
Population genetics
Public Health
Regression analysis
Single-nucleotide polymorphism
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Summary:Background/Objectives Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. Subjects/Methods We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region. Results We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values
ISSN:0954-3007
1476-5640
DOI:10.1038/s41430-020-00823-z