Evaluation of serum interleukin-33 and gene polymorphisms in patients with bronchial asthma

Aims: Asthma is a chronic inflammatory disease of the airways. The aim of the study was to investigate the association between serum interleukin (IL)-33 level and IL-33 gene rs1342326, rs1929992 and rs3939286 polymorphisms in patients with asthma. Methods: Ninety patients aged 18 years and older, wh...

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Bibliographic Details
Published in:Gulhane Medical Journal 2021-06, Vol.63 (2), p.104-109
Main Authors: Canoglu, Kadir, Okutan, Oguzhan, Tas, Dilaver, Yilmaz, Ismail, Yesilbas, Soner, Caliskan, Tayfun, Kosar, Ayse Filiz Arpacag, Kartaloglu, Zafer, Ayten, Omer, Uyar, Yasin
Format: Article
Language:English
Subjects:
Age
Asthma
Care and treatment
Comparative analysis
Cytokines
Disease
Enzyme-linked immunosorbent assay
Enzymes
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Genetic polymorphisms
Genotype & phenotype
Health aspects
Health care
Independent sample
Interleukins
Pathogenesis
Patients
Polymorphism
Software
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Summary:Aims: Asthma is a chronic inflammatory disease of the airways. The aim of the study was to investigate the association between serum interleukin (IL)-33 level and IL-33 gene rs1342326, rs1929992 and rs3939286 polymorphisms in patients with asthma. Methods: Ninety patients aged 18 years and older, who were diagnosed with asthma, and 90 healthy control subjects were included in the study. Serum IL-33 levels were measured by enzyme-linked immunosorbent assay; and IL-33 gene polymorphisms were studied by real-time polymerase chain reaction. Results: IL-33 level was higher in patients with asthma (4.16 [+ or -] 0.88 pg/mL) compared to the control subjects (1.28 [+ or -] 0.37 pg/mL) (p
ISSN:1302-0471
2146-8052
DOI:10.4274/gulhane.galenos.2020.1438