Evaluation of serum interleukin-33 and gene polymorphisms in patients with bronchial asthma

Aims: Asthma is a chronic inflammatory disease of the airways. The aim of the study was to investigate the association between serum interleukin (IL)-33 level and IL-33 gene rs1342326, rs1929992 and rs3939286 polymorphisms in patients with asthma. Methods: Ninety patients aged 18 years and older, wh...

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Published in:Gulhane Medical Journal 2021-06, Vol.63 (2), p.104-109
Main Authors: Canoglu, Kadir, Okutan, Oguzhan, Tas, Dilaver, Yilmaz, Ismail, Yesilbas, Soner, Caliskan, Tayfun, Kosar, Ayse Filiz Arpacag, Kartaloglu, Zafer, Ayten, Omer, Uyar, Yasin
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Subjects:
Age
Asthma
Care and treatment
Comparative analysis
Cytokines
Disease
Enzyme-linked immunosorbent assay
Enzymes
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Genetic polymorphisms
Genotype & phenotype
Health aspects
Health care
Independent sample
Interleukins
Pathogenesis
Patients
Polymorphism
Software
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container_issue 2
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container_title Gulhane Medical Journal
container_volume 63
creator Canoglu, Kadir
Okutan, Oguzhan
Tas, Dilaver
Yilmaz, Ismail
Yesilbas, Soner
Caliskan, Tayfun
Kosar, Ayse Filiz Arpacag
Kartaloglu, Zafer
Ayten, Omer
Uyar, Yasin
description Aims: Asthma is a chronic inflammatory disease of the airways. The aim of the study was to investigate the association between serum interleukin (IL)-33 level and IL-33 gene rs1342326, rs1929992 and rs3939286 polymorphisms in patients with asthma. Methods: Ninety patients aged 18 years and older, who were diagnosed with asthma, and 90 healthy control subjects were included in the study. Serum IL-33 levels were measured by enzyme-linked immunosorbent assay; and IL-33 gene polymorphisms were studied by real-time polymerase chain reaction. Results: IL-33 level was higher in patients with asthma (4.16 [+ or -] 0.88 pg/mL) compared to the control subjects (1.28 [+ or -] 0.37 pg/mL) (p
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The aim of the study was to investigate the association between serum interleukin (IL)-33 level and IL-33 gene rs1342326, rs1929992 and rs3939286 polymorphisms in patients with asthma. Methods: Ninety patients aged 18 years and older, who were diagnosed with asthma, and 90 healthy control subjects were included in the study. Serum IL-33 levels were measured by enzyme-linked immunosorbent assay; and IL-33 gene polymorphisms were studied by real-time polymerase chain reaction. Results: IL-33 level was higher in patients with asthma (4.16 [+ or -] 0.88 pg/mL) compared to the control subjects (1.28 [+ or -] 0.37 pg/mL) (p&lt;0.001). The frequencies of AA, CC and AC alleles for the rs1342326 polymorphism were 52 (57.8%), 5 (5.6%) and 33 (36.7%) in the patient group, and 53 (58.9%), 7 (7.8%) and 30 (33.3%) in the control group, respectively. The frequencies of CC, TT and CT alleles for the rs1929992 polymorphism were 17 (18.9%), 31 (34.4%), and 42 (46.7%) in the patient group and 13 (14.4%), 41 (45.6%), and 36 (40%) in the control group, respectively. The frequencies of CC, TT and CT alleles for the rs3939286 polymorphism were 46 (51.1%), 7 (7.8%), and 37 (41.1%) in the patient group and 44 (48.9%), 9 (10%), and 37 (41.1%) in the control group, respectively. There was no statistically significant difference between the groups in terms of IL-33 gene polymorphisms (rs1342326, rs1929992 and rs3939286) (p=0.784, p=0.304, p=0.863, respectively). Conclusions: The current study showed increased serum IL-33 levels in patients with asthma compared to healthy controls but gene polymorphism studies did not show any significant difference. Keywords: Asthma, IL-33, cytokine</description><identifier>ISSN: 1302-0471</identifier><identifier>EISSN: 2146-8052</identifier><identifier>DOI: 10.4274/gulhane.galenos.2020.1438</identifier><language>eng</language><publisher>Ankara: Galenos Yayinevi Tic. Ltd</publisher><subject>Age ; Asthma ; Care and treatment ; Comparative analysis ; Cytokines ; Disease ; Enzyme-linked immunosorbent assay ; Enzymes ; Ethylenediaminetetraacetic acid ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genotype &amp; phenotype ; Health aspects ; Health care ; Independent sample ; Interleukins ; Pathogenesis ; Patients ; Polymorphism ; Software</subject><ispartof>Gulhane Medical Journal, 2021-06, Vol.63 (2), p.104-109</ispartof><rights>COPYRIGHT 2021 Galenos Yayinevi Tic. Ltd.</rights><rights>2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-1579-3392 ; 0000-0003-2785-2492 ; 0000-0001-6767-5246 ; 0000-0002-4660-1595 ; 0000-0002-2275-4378 ; 0000-0002-1288-6115 ; 0000-0003-2163-1795 ; 0000-0001-5707-2716 ; 0000-0002-2954-6168 ; 0000-0002-7905-2430</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2539885915/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2539885915?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,44590,75126</link.rule.ids></links><search><creatorcontrib>Canoglu, Kadir</creatorcontrib><creatorcontrib>Okutan, Oguzhan</creatorcontrib><creatorcontrib>Tas, Dilaver</creatorcontrib><creatorcontrib>Yilmaz, Ismail</creatorcontrib><creatorcontrib>Yesilbas, Soner</creatorcontrib><creatorcontrib>Caliskan, Tayfun</creatorcontrib><creatorcontrib>Kosar, Ayse Filiz Arpacag</creatorcontrib><creatorcontrib>Kartaloglu, Zafer</creatorcontrib><creatorcontrib>Ayten, Omer</creatorcontrib><creatorcontrib>Uyar, Yasin</creatorcontrib><title>Evaluation of serum interleukin-33 and gene polymorphisms in patients with bronchial asthma</title><title>Gulhane Medical Journal</title><description>Aims: Asthma is a chronic inflammatory disease of the airways. The aim of the study was to investigate the association between serum interleukin (IL)-33 level and IL-33 gene rs1342326, rs1929992 and rs3939286 polymorphisms in patients with asthma. Methods: Ninety patients aged 18 years and older, who were diagnosed with asthma, and 90 healthy control subjects were included in the study. Serum IL-33 levels were measured by enzyme-linked immunosorbent assay; and IL-33 gene polymorphisms were studied by real-time polymerase chain reaction. Results: IL-33 level was higher in patients with asthma (4.16 [+ or -] 0.88 pg/mL) compared to the control subjects (1.28 [+ or -] 0.37 pg/mL) (p&lt;0.001). The frequencies of AA, CC and AC alleles for the rs1342326 polymorphism were 52 (57.8%), 5 (5.6%) and 33 (36.7%) in the patient group, and 53 (58.9%), 7 (7.8%) and 30 (33.3%) in the control group, respectively. The frequencies of CC, TT and CT alleles for the rs1929992 polymorphism were 17 (18.9%), 31 (34.4%), and 42 (46.7%) in the patient group and 13 (14.4%), 41 (45.6%), and 36 (40%) in the control group, respectively. The frequencies of CC, TT and CT alleles for the rs3939286 polymorphism were 46 (51.1%), 7 (7.8%), and 37 (41.1%) in the patient group and 44 (48.9%), 9 (10%), and 37 (41.1%) in the control group, respectively. There was no statistically significant difference between the groups in terms of IL-33 gene polymorphisms (rs1342326, rs1929992 and rs3939286) (p=0.784, p=0.304, p=0.863, respectively). Conclusions: The current study showed increased serum IL-33 levels in patients with asthma compared to healthy controls but gene polymorphism studies did not show any significant difference. 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The aim of the study was to investigate the association between serum interleukin (IL)-33 level and IL-33 gene rs1342326, rs1929992 and rs3939286 polymorphisms in patients with asthma. Methods: Ninety patients aged 18 years and older, who were diagnosed with asthma, and 90 healthy control subjects were included in the study. Serum IL-33 levels were measured by enzyme-linked immunosorbent assay; and IL-33 gene polymorphisms were studied by real-time polymerase chain reaction. Results: IL-33 level was higher in patients with asthma (4.16 [+ or -] 0.88 pg/mL) compared to the control subjects (1.28 [+ or -] 0.37 pg/mL) (p&lt;0.001). The frequencies of AA, CC and AC alleles for the rs1342326 polymorphism were 52 (57.8%), 5 (5.6%) and 33 (36.7%) in the patient group, and 53 (58.9%), 7 (7.8%) and 30 (33.3%) in the control group, respectively. The frequencies of CC, TT and CT alleles for the rs1929992 polymorphism were 17 (18.9%), 31 (34.4%), and 42 (46.7%) in the patient group and 13 (14.4%), 41 (45.6%), and 36 (40%) in the control group, respectively. The frequencies of CC, TT and CT alleles for the rs3939286 polymorphism were 46 (51.1%), 7 (7.8%), and 37 (41.1%) in the patient group and 44 (48.9%), 9 (10%), and 37 (41.1%) in the control group, respectively. There was no statistically significant difference between the groups in terms of IL-33 gene polymorphisms (rs1342326, rs1929992 and rs3939286) (p=0.784, p=0.304, p=0.863, respectively). Conclusions: The current study showed increased serum IL-33 levels in patients with asthma compared to healthy controls but gene polymorphism studies did not show any significant difference. Keywords: Asthma, IL-33, cytokine</abstract><cop>Ankara</cop><pub>Galenos Yayinevi Tic. 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subjects Age
Asthma
Care and treatment
Comparative analysis
Cytokines
Disease
Enzyme-linked immunosorbent assay
Enzymes
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Genetic polymorphisms
Genotype & phenotype
Health aspects
Health care
Independent sample
Interleukins
Pathogenesis
Patients
Polymorphism
Software
title Evaluation of serum interleukin-33 and gene polymorphisms in patients with bronchial asthma
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