Tumor Regression Grade in Gastric Cancer After Preoperative Therapy

Background The Cancer Staging Manual , 8th edition, now includes post-neoadjuvant therapy (ypTNM) staging for gastric cancer patients. Our purpose was to determine whether the tumor regression grade (TRG) of the primary tumor is useful for predicting the survival of these patients. Methods We perfor...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastrointestinal surgery 2021-06, Vol.25 (6), p.1380-1387
Main Authors: Ikoma, Naruhiko, Estrella, Jeannelyn S., Blum Murphy, Mariela, Das, Prajnan, Minsky, Bruce D., Mansfield, Paul, Ajani, Jaffer A., Badgwell, Brian D.
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Cancer therapies
Chemotherapy
Ethnicity
Gastric cancer
Gastroenterology
Gastrointestinal surgery
Humans
Lymphatic system
Medicine
Medicine & Public Health
Metastasis
Neoadjuvant Therapy
Neoplasm Staging
Oncology
Original Article
Pathology
Prognosis
Radiation
Retrospective Studies
Stomach Neoplasms - pathology
Stomach Neoplasms - therapy
Surgery
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The Cancer Staging Manual , 8th edition, now includes post-neoadjuvant therapy (ypTNM) staging for gastric cancer patients. Our purpose was to determine whether the tumor regression grade (TRG) of the primary tumor is useful for predicting the survival of these patients. Methods We performed a retrospective review of an institutional database and identified patients with clinically non-metastatic gastric adenocarcinoma who underwent preoperative chemotherapy or chemoradiation therapy before gastrectomy. Pathology reports were reviewed, and TRG was classified as follows: 0 (complete response), 1 (viable tumor cells ≤ 1–2%), 2 (viable cells ≤ 50%), or 3 (viable cells > 50%). Results Of the 356 patients identified, including 80 (23%) with a gastroesophageal junction tumor, 268 (75%) had undergone preoperative chemoradiation therapy. Fifty-six (16%) had TRG 0, 57 (16%) TRG 1, 128 (36%) TRG 2, and 115 (32%) TRG 3. No association between TRG and pretreatment factors was identified, except for signet-ring cell histologic type and tumor location. A higher TRG was associated with more advanced ypT and ypN categories (both p  
ISSN:1091-255X
1873-4626
DOI:10.1007/s11605-020-04688-2