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Biomimetic Nanomedicine Coupled with Neoadjuvant Chemotherapy to Suppress Breast Cancer Metastasis via Tumor Microenvironment Remodeling

The biomimetic enzyme activity of cerium oxide nanoparticles (CeNPs) prefers ultrasmall particle size and bare surface. Unfortunately, those two features are not favorable for its in vivo application due to easy aggregation and fast renal filtration. To take advantage of the activity of CeNP for can...

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Published in:Advanced functional materials 2021-06, Vol.31 (25), p.n/a
Main Authors: Liu, Hai‐jun, Wang, Junfeng, Wang, Mingming, Wang, Yuzhen, Shi, Shanshan, Hu, Xiangxiang, Zhang, Quanguang, Fan, Daping, Xu, Peisheng
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cited_by cdi_FETCH-LOGICAL-c3172-d1e5318196321384feaaf34de187ae58a5c83ccb16be57ca15109ed2bdbe6c973
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container_title Advanced functional materials
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creator Liu, Hai‐jun
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description The biomimetic enzyme activity of cerium oxide nanoparticles (CeNPs) prefers ultrasmall particle size and bare surface. Unfortunately, those two features are not favorable for its in vivo application due to easy aggregation and fast renal filtration. To take advantage of the activity of CeNP for cancer therapy, a homologous targeted cerium oxide nanoparticle system, targeted CeNP (T‐CeNP), with the integration of a biodegradable dendritic mesoporous silica nanoparticle, superoxide dismutase and catalase mimicking CeNPs, and the camouflage coating of cancer cell membrane has been developed. Attributed to the homologous targeting effect of cancer cell membrane, nanoparticles with camouflage coating are retained in the tumor in an orthotopic breast cancer metastatic model. Subsequently, T‐CeNP effectively hinders cancer‐associated fibroblast transdifferentiation and reprograms it back to a normal fibroblast. Consequently, T‐CeNP coupled with doxorubicin reduces the size of primary tumors and prevents the post‐surgery lung metastasis and liver metastasis of breast cancer. A homologous targeted cerium oxide nanoparticle system (T‐CeNP) is developed for remodeling the tumor microenvironment by inhibiting cancer‐associated fibroblast transdifferentiation and reprogramming them back to normal fibroblasts. T‐CeNP coupled with doxorubicin reduces the size of the primary tumor and prevents post‐surgery lung metastasis and liver metastasis of cancer in an orthotopic breast cancer model.
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Unfortunately, those two features are not favorable for its in vivo application due to easy aggregation and fast renal filtration. To take advantage of the activity of CeNP for cancer therapy, a homologous targeted cerium oxide nanoparticle system, targeted CeNP (T‐CeNP), with the integration of a biodegradable dendritic mesoporous silica nanoparticle, superoxide dismutase and catalase mimicking CeNPs, and the camouflage coating of cancer cell membrane has been developed. Attributed to the homologous targeting effect of cancer cell membrane, nanoparticles with camouflage coating are retained in the tumor in an orthotopic breast cancer metastatic model. Subsequently, T‐CeNP effectively hinders cancer‐associated fibroblast transdifferentiation and reprograms it back to a normal fibroblast. Consequently, T‐CeNP coupled with doxorubicin reduces the size of primary tumors and prevents the post‐surgery lung metastasis and liver metastasis of breast cancer. 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subjects Biodegradability
Biomimetics
Breast cancer
Camouflage
cancer metastasis
cancer‐associated fibroblast
Catalase
Cell membranes
cerium oxide nanoparticle
Cerium oxides
Doxorubicin
Enzyme activity
Fibroblasts
homologous targeting
Homology
Materials science
Metastasis
Nanoparticles
Silicon dioxide
Superoxide dismutase
tumor microenvironment
Tumors
title Biomimetic Nanomedicine Coupled with Neoadjuvant Chemotherapy to Suppress Breast Cancer Metastasis via Tumor Microenvironment Remodeling
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