An Integrated Detection Method for Flow Viscosity Measurements in Microdevices

Point-of-care devices can analyze or characterize a sample in a short time. New technologies in medical science seek integrations of different measurement techniques for a complete analysis. This study describes the fabrication method, tests, and results of microtechnology as an approach for an inte...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2021-07, Vol.68 (7), p.2049-2057
Main Authors: Rodriguez-Villarreal, Angeles I., Tana, Laura Ortega, Cid, Joan, Hernandez-Machado, Aurora, Alarcon, Tomas, Miribel-Catala, Pere, Colomer-Farrarons, Jordi
Format: Article
Language:English
Subjects:
Aqueous solutions
Biomedical materials
Biomedical measurement
Biomedical monitoring
Blood
Data acquisition
electrical
Electrodes
Fabrication
Flow velocity
LOC
Measurement techniques
Medical science
Microchannels
Microfluidics
microsensor
New technology
Newtonian fluids
point-of-Care
Portable equipment
Pumps
rheometer
Shear rate
viscometer
Viscosity
Viscosity measurement
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Summary:Point-of-care devices can analyze or characterize a sample in a short time. New technologies in medical science seek integrations of different measurement techniques for a complete analysis. This study describes the fabrication method, tests, and results of microtechnology as an approach for an integrated rheometer. The portable device measured the average flow velocity to calculate its viscosity. The whole system encompasses a microdevice integrated to a data acquisition system powered by USB and controlled by full custom software. As a result, we obtained an easy-to-handle and fabricate hand-held microrheometer. The device was tested using Newtonian fluids such as Mili-Q water, an aqueous solution of Ethylene-glycol at 40% and 25% and Non-Newtonian blood samples. The whole device can provide the non-linear viscosity of a 0.08 ml blood sample in less than 30 seconds, in a wide range of shear rate with an accuracy of 93%. More importantly, due to its detection method and simplicity, it can be enclosed within almost any fluidic microsystem, including biomedical applications.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2020.3013519