Investigation of the Effect of the Antiaggregant Agent Ticagrelor on the Electrical and Mechanical Activities of Rat Heart With Type 1 Diabetes

• Published in: Ankara Ueniversitesi Tip Fakültesi mecmuasi 2021-08, Vol.74 (2), p.206-212
• Main Authors: Durak, Ayşegül, Tuncay, Erkan, Değirmenci, Sinan, Turan, Belma
• Format: Article
• Language: eng ; tur
• Subjects: Diabetes; Glucose; Heart
• ISSN: 1307-5608; 0365-8104; 1307-5608
• DOI: 10.4274/atfm.galenos.2021.98216

Objectives: Diabetes mellitus (DM) is presently a worldwide health problem and leads to high risks for cardiovascular disfunction. Besides vascular disorders in dependent diabetic-cardiomyopathy, high thrombocyte reactivity is developed in DM. In this study, we aimed to examine the effect of P2Y12 receptor blocker ticagrelor (TICA) on heart function of DM rats. Materials and Methods: DM was induced by a single-dose of streptozotocin (STZ) injection in 3-month-old Wistar male rats (250-300g) and confirmed by blood glucose level, 48-hour following STZ-injection. After DM confirmation, those animals were kept for 8 weeks and then, they were divided into two groups. One half DM rats was treated with TICA (150 mg/kg/day, orally) for 4 weeks (DM+TICA group), while the second half group was treated with water (DM group). A third group of rats was treated with only water (Con-group). In situ electrocardiography (ECG)-recording was performed under mild anesthesia and mechanical activities of isolated hearts were examined by Langendorff-perfusion-system. Results: The body weight of the DM group was significantly reduced compared to the Con group (p0.05). Furthermore, TICA treatment did not affect reduced left ventricular pressure and increased left ventricular end-diastolic pressure of the DM group. However, TICA treatment was further prolonged half relaxation time of left ventricular pressure, which was also prolonged in the DM group (p