Curative effect of TFX-Jelfa supplementation on the skin of ovariectomised rats – morphological study

The aim of this study was to assess the effect of thymus factor X (TFX-Jelfa) treatment in hypoestrogenic female rats for the purpose of decreasing skin impairments. Ovariectomised rats were used as a model. The histopathological analysis of the skin after TFX-Jelfa treatment demonstrated that the e...

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Bibliographic Details
Published in:Bulletin of the Veterinary Institute in Puławy 2015-06, Vol.59 (2), p.311-315
Main Authors: Karpińska, Teresa Agnieszka, Szpringer, Ewa, Lutnicki, Krzysztof, Wasiak, Magdalena, Reichert, Michał
Format: Article
Language:English
Subjects:
Aging
aging skin
Cell proliferation
Coagulation factors
Collagen
Dendritic cells
Dermis
Epidermis
Fibroblasts
Follicles
histopathology
Keratinocytes
rats
Skin
Supplements
Thymus
Thymus gland
thymus hormones
ultrastructural examination
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Summary:The aim of this study was to assess the effect of thymus factor X (TFX-Jelfa) treatment in hypoestrogenic female rats for the purpose of decreasing skin impairments. Ovariectomised rats were used as a model. The histopathological analysis of the skin after TFX-Jelfa treatment demonstrated that the epidermis was thicker and more desquamated, without deep wrinkles or hypersecretion in comparison to the skin of animals only castrated and not treated with TFX-Jelfa. Collagen and elastic fibres were arranged more uniformly in the dermis and there were numerous fibroblasts, hair follicles, and small vessels. Ultrastructural analysis showed keratinocytes without degenerative changes and the proliferation of lymphatic and dendritic cells in the skin. The results indicate that thymus extracts can have beneficial effects on skin aging, which is often accompanied by hormonal perturbances.
ISSN:2300-3235
2450-7393
2300-3235
2450-8608
DOI:10.1515/bvip-2015-0045