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Selected parameters of immune response in pregnant sows vaccinated against Trueperella pyogenes

Expression of CD4, CD8, and CD25 surface markers on T lymphocytes and levels of IFNγ, IL-10, and TNF-α in colostrum and milk were determined in sows vaccinated against Trueperella pyogenes in the final stage of pregnancy. The autovaccine, prepared from Trueperella pyogenes, administered twice to pre...

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Bibliographic Details
Published in:Bulletin of the Veterinary Institute in Puławy 2014-01, Vol.58 (1), p.17-21
Main Authors: Kostro, Krzysztof, Lisiecka, Urszula, Żmuda, Andrzej, Niemczuk, Krzysztof, Stojecki, Krzysztof, Taszkun, Iwona
Format: Article
Language:English
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Summary:Expression of CD4, CD8, and CD25 surface markers on T lymphocytes and levels of IFNγ, IL-10, and TNF-α in colostrum and milk were determined in sows vaccinated against Trueperella pyogenes in the final stage of pregnancy. The autovaccine, prepared from Trueperella pyogenes, administered twice to pregnant sows six and three weeks before the anticipated delivery significantly increased the percentages of TCD4+, TCD8+, and TCD25+ as well as levels of IFNγ, TNF-α, and IL-10 in colostrum and milk. The enhanced immune potential of colostrum effectively protected the piglets against T. pyogenes infections during weaning and thus reduced the economic losses on the particular farm concerned, where T. pyogenes infections occur endemically. Knowledge of the profile of cellular and humoral immune response in colostrum and milk of vaccinated sows will enable the design of a T. pyogenes infection prophylactic programme for suckling pigs and weaners, which are most susceptible to infections.
ISSN:2300-3235
2450-7393
2300-3235
2450-8608
DOI:10.2478/bvip-2014-0003