Substitution in position 222 of haemagglutinin of pandemic influenza A (H1N1) viruses isolated from pigs in Poland

The aim of the study was to monitor genetic diversity and antigenic changes in the genome of influenza A(H1N1)pdm09 viral isolates detected during the post-pandemic period in Poland. Clinical specimens obtained from three suspected cases of influenza were analysed by sequencing. Among the difference...

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Bibliographic Details
Published in:Bulletin of the Veterinary Institute in Puławy 2015-12, Vol.59 (4), p.451-456
Main Authors: Kowalczyk, Andrzej, Urbaniak, Kinga, Markowska-Daniel, Iwona, Pejsak, Zygmunt
Format: Article
Language:English
Subjects:
Genetic diversity
Genomes
Hemagglutinins
Influenza
Influenza A
mutagenesis
Mutation
pandemic influenza
Pandemics
Swine flu
swine influenza virus
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Summary:The aim of the study was to monitor genetic diversity and antigenic changes in the genome of influenza A(H1N1)pdm09 viral isolates detected during the post-pandemic period in Poland. Clinical specimens obtained from three suspected cases of influenza were analysed by sequencing. Among the differences identified in amino acids sequences, nine substitutions were located within the antigenic HA1 sites and in five residues forming receptor-binding pocket. The HA(D222G) mutation was shown in the isolate Swine/Poland/134312/12 obtained from a mild case of the disease. It must be emphasized that, in general, clinically mild cases are caused by the viruses in which that specific mutation, i.e. haemagglutinin (D222G), does not occur.
ISSN:2300-3235
2450-7393
2300-3235
2450-8608
DOI:10.1515/bvip-2015-0066