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Recent advances in [3+2] cycloaddition of allenes with 1,3-carbonyl ylides; Rh()-catalyzed access to bridged polyoxocarbocyles
This study summarizes the stereochemical outcomes of [3+2] cycloaddition of allene molecules with 1,3-dipolar carbonyl ylides derived from rhodium carbene-mediated diazo decomposition for the formation of highly diastereoselective poly oxacarbocycles. Since only rhodium is employed for this purpose,...
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Published in: | New journal of chemistry 2021-07, Vol.45 (25), p.1118-1129 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | This study summarizes the stereochemical outcomes of [3+2] cycloaddition of allene molecules with 1,3-dipolar carbonyl ylides derived from rhodium carbene-mediated diazo decomposition for the formation of highly diastereoselective poly oxacarbocycles. Since only rhodium is employed for this purpose, further exploration of the reaction with other transition metals is lacking. A little research in this area surely depicts the need for further exploration of this technique using other transition metals and ylides (sulfur and nitrogen) for the synthesis of oxa-, aza-, and thia-bridged heterocarbocycles. These polyheterocycles will be future drug candidates being structurally analogous to anthecularin, artemisinin, englerin and intracarene. This review presents a future outlook for organic chemists for further exploration of the synthesis of bridged polyheterocarbocycles.
This study summarizes the stereochemical outcomes of [3+2] cycloaddition of allene molecules with 1,3-dipolar carbonyl ylides derived from Rh(
ii
) carbene-mediated diazo decomposition for the formation of highly diastereoselective poly oxacarbocycles. |
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ISSN: | 1144-0546 1369-9261 |
DOI: | 10.1039/d1nj02034j |