Pleurotus Eryngii Ekstraktının Sprague-Dawley Sıçanlarında Adriamisin Kaynaklı Kardiyotoksisite Üzerindeki Etkilerinin İncelenmesi

For this reason, in this study, it was aimed to examine the protective effect of Pleurotus eryngii extract (PEE) on the changes occurring in the heart tissues of rats treated with ADR. Results: Inflammatory cell increase, loss of myofibril, cytoplasmic vacuolization, and vascular congestion were fou...

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Bibliographic Details
Published in:Dicle tıp dergisi 2021-06, Vol.48 (2), p.328-337
Main Authors: Güzel, Elif Erdem, Tektemur, Nalan Kaya, Tektemur, Ahmet, Acay, Hilal, Yıldırım, Ayfer
Format: Article
Language:Turkish
Subjects:
Cardiotoxicity
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Summary:For this reason, in this study, it was aimed to examine the protective effect of Pleurotus eryngii extract (PEE) on the changes occurring in the heart tissues of rats treated with ADR. Results: Inflammatory cell increase, loss of myofibril, cytoplasmic vacuolization, and vascular congestion were found in the heart tissues belonging to ADR group. [...]a significant increase in IL1-ß immunoreactivity and IL1-ß, BAX, Caspase-3 mRNA levels were observed in the ADR group compared to the control group. K0915, Polyclonal Anti-IL-1ß Antibody, Santa Cruz Biotechnology) damlatıldı ve dokular bir saat oda ısısında karanlık ve nemli ortamda inkübe edildi. İnkübasyonun ardından sekonder antikor (TP-060-BN, Biotinylated Goat AntiPoliyvalent (anti-mouse / rabbit IgG), Thermo Scientific) uygulandı.
ISSN:1300-2945
1308-9889
DOI:10.5798/dicletip.944395