Pleurotus Eryngii Ekstraktının Sprague-Dawley Sıçanlarında Adriamisin Kaynaklı Kardiyotoksisite Üzerindeki Etkilerinin İncelenmesi

For this reason, in this study, it was aimed to examine the protective effect of Pleurotus eryngii extract (PEE) on the changes occurring in the heart tissues of rats treated with ADR. Results: Inflammatory cell increase, loss of myofibril, cytoplasmic vacuolization, and vascular congestion were fou...

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Published in:Dicle tıp dergisi 2021-06, Vol.48 (2), p.328-337
Main Authors: Güzel, Elif Erdem, Tektemur, Nalan Kaya, Tektemur, Ahmet, Acay, Hilal, Yıldırım, Ayfer
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Cardiotoxicity
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container_title Dicle tıp dergisi
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Tektemur, Nalan Kaya
Tektemur, Ahmet
Acay, Hilal
Yıldırım, Ayfer
description For this reason, in this study, it was aimed to examine the protective effect of Pleurotus eryngii extract (PEE) on the changes occurring in the heart tissues of rats treated with ADR. Results: Inflammatory cell increase, loss of myofibril, cytoplasmic vacuolization, and vascular congestion were found in the heart tissues belonging to ADR group. [...]a significant increase in IL1-ß immunoreactivity and IL1-ß, BAX, Caspase-3 mRNA levels were observed in the ADR group compared to the control group. K0915, Polyclonal Anti-IL-1ß Antibody, Santa Cruz Biotechnology) damlatıldı ve dokular bir saat oda ısısında karanlık ve nemli ortamda inkübe edildi. İnkübasyonun ardından sekonder antikor (TP-060-BN, Biotinylated Goat AntiPoliyvalent (anti-mouse / rabbit IgG), Thermo Scientific) uygulandı.
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title Pleurotus Eryngii Ekstraktının Sprague-Dawley Sıçanlarında Adriamisin Kaynaklı Kardiyotoksisite Üzerindeki Etkilerinin İncelenmesi
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