Pre-Treatment Lymphopenia and NLR May Have Prognostic Value in Turkish High-Grade Glial Tumor Patients

Objectives: We aimed to determine the prognostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lym?phocyte ratio (PLR), and lymphocytopenia in Turkish high-grade glial tumor patients. Methods: This study was designed as a hospital-based retrospective observational case series study....

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Bibliographic Details
Published in:Eurasian journal of medical investigation 2021, Vol.5 (1), p.107
Main Author: Sedef, Ali Murat
Format: Article
Language:eng ; tur
Subjects:
Biomarkers
Brain cancer
Brain research
Ethics
Hospitals
Inflammation
Localization
Lymphocytes
Medical prognosis
Neutrophils
Oncology
Patients
Tumors
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Summary:Objectives: We aimed to determine the prognostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lym?phocyte ratio (PLR), and lymphocytopenia in Turkish high-grade glial tumor patients. Methods: This study was designed as a hospital-based retrospective observational case series study. A total of 111 patients with recurrent glioblastoma multiforme (GBM) at four different oncology centers in Turkey between 2009 and 2017 have included to our study. Results: All of the patients (n=111) had recurrent disease. Sixty-nine (62.2%) patients died and overall survival (OS) was estimated 28 months. Cutoff NLR value is found as 3.06. The OS of patients who had low NLR was statistically significantly longer than the patients who had high NLR (30 months vs. 23 months, p=0.008). The OS of patients with lymphocytopenia was statistically significantly worse than the other group (24 months vs. 30 months, p=0.04). Progres?sion-free survival was estimated 8 months. Median PFS was statistically better in GBM than the astrocytoma (8 months vs. 4 months, p=0.03). Conclusion: In our study, we showed that high NLR and lymphocytopenia may also have prognostic value in recurrent Turkish high-grade glial tumor patients and the present findings confirm that these markers may be used to predict the mortality risks for these patients.
ISSN:2602-3164
2602-3164
DOI:10.14744/ejmi.2021.12734