Relationship of Serum Copper and Zinc Levels with Plasma NT-proBNP Level in Men with Ischemic Origin Chronic Heart Failure

Objectives: Heart failure (HF) is one of the main causes of cardiovascular mortality and mobidity today. Despite all the advances in the diagnosis and treatment of HF, mortality and morbidity rates could not be reduced to the desired levels. Therefore, it is important to identify new prognostic fact...

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Bibliographic Details
Published in:Eurasian journal of medical investigation 2021, Vol.5 (2), p.172
Main Author: Aksu, Ekrem
Format: Article
Language:eng ; tur
Subjects:
Heart failure
Medical prognosis
Mortality
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Summary:Objectives: Heart failure (HF) is one of the main causes of cardiovascular mortality and mobidity today. Despite all the advances in the diagnosis and treatment of HF, mortality and morbidity rates could not be reduced to the desired levels. Therefore, it is important to identify new prognostic factors in these patients. Recent studies show that micro?nutrient dyshomeostasis may play a role in the pathophysiology of HF. In this study, it was aimed to investigate the relationship between copper (Cu), zinc (Zn) and Cu / Zn ratio and N-terminal pro-B type natriuretic peptide (NT-proBNP) levels in male patients followed with ischemic HF. Methods: 57 male patients who were followed up in the cardiology outpatient clinic with a diagnosis of compensated chronic HF of ischemic origin were divided into two groups as high and low according to the NT-proBNP level, whose prognostic limit value was reported as 1000 ng / L. The control group was composed of 24 patients with similar demo?graphic characteristics, except for the presence of HF. Results: In the high nt-proBNP group, the serum Cu mean level was low compared to the nt-proBNP group (p
ISSN:2602-3164
2602-3164
DOI:10.14744/ejmi.2021.79007