Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9-tetrahydrocannabinol

INTRODUCTION: In recent years, cannabinoids have been shown to have beneficial effects on diabetic vascular complications. Vascular complications due to fructose-induced hyperinsulinemia (HI) and diabetic vascular complications have similar mechanisms. The aim of this experimental study was to obser...

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Bibliographic Details
Published in:International journal of medical biochemistry 2021-01, Vol.4 (1), p.50
Main Authors: Zeynep Gizem Todurga Seven, Köse, Çağla, Zeynep Mine Coşkun, Gökdemir, Selim, Akkan, Ahmet Gökhan, Bolkent, Sema, Özyazgan, Sibel
Format: Article
Language:English
Subjects:
Diabetes
Tetrahydrocannabinol
THC
Online Access:Get full text
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Summary:INTRODUCTION: In recent years, cannabinoids have been shown to have beneficial effects on diabetic vascular complications. Vascular complications due to fructose-induced hyperinsulinemia (HI) and diabetic vascular complications have similar mechanisms. The aim of this experimental study was to observe whether the cannabinoid agonist delta-9-tetrahydrocannabinol (THC) has an ameliorating effect on fructose-induced HI and vascular responses in the aortic ring of rats with HI. METHODS: A total of 24 rats were categorized into 4 groups: control (standard food pellets and water), HI (water containing 10% fructose provided for 12 weeks), THC (1.5 mg/kg/day intraperitoneal administration for 4 weeks), and THC+HI. Body weight was measured again on the last day of the study and the serum insulin level was measured with an enzyme-linked immunosorbent assay. The acetylcholine (ACh) maximum relaxant effect in aortic rings pre-contracted with noradrenaline (NA) was evaluated. RESULTS: The body weight of THC and THC+HI groups was lower compared with that of the controls (p
ISSN:2587-2362
2618-642X
DOI:10.14744/ijmb.2020.83703