Importance of some factors on the Suzuki‐Miyaura cross‐coupling reaction

This review was designed to give an overview of the significant parameters in Suzuki‐Miyaura coupling (SMC) reactions, which are a powerful tool for the formation of the carbon–carbon (CC) bond. Since the SMC reaction depends on factors such as solvent, base, temperature, time, catalyst amount, sub...

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Bibliographic Details
Published in:Journal of the Chinese Chemical Society (Taipei) 2021-06, Vol.68 (6), p.942-951
Main Author: Akkoç, Senem
Format: Article
Language:English
Subjects:
Aromatic compounds
Carbon
carbon–carbon coupling
catalyst
Cross coupling
Halides
Parameters
Substrates
Suzuki‐Miyaura
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Summary:This review was designed to give an overview of the significant parameters in Suzuki‐Miyaura coupling (SMC) reactions, which are a powerful tool for the formation of the carbon–carbon (CC) bond. Since the SMC reaction depends on factors such as solvent, base, temperature, time, catalyst amount, substituent in aryl halides, and molar ratios of the substrates, all these parameters should be screened for a successful SMC reaction. After finding the optimum reaction conditions, the SMC reaction's products of boronic acid derivatives with aryl halides can be obtained in high yields. The parameters such as solvent, base, temperature, time, amount of catalyst, and pH can play a significant role on catalytic activity results (yields/conversions) of a Suzuki‐Miyaura coupling reaction, and the optimum conditions change from reaction to reaction.
ISSN:0009-4536
2192-6549
DOI:10.1002/jccs.202000351