Se@Albumin nanoparticles ameliorate intestinal mucositis caused by cisplatin via gut microbiota-targeted regulation

Chemotherapy-associated intestinal mucositis is still one of the major challenges in the first-line clinical cancer treatment. Selenium element has shown health benefits on enteritis upon uptake in trace amounts; however, it was limited because of its narrow safety margin. In this work, a new form o...

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Bibliographic Details
Published in:Nanoscale 2021-07, Vol.13 (25), p.11250-11261
Main Authors: Deng, Liping, Zeng, Hongliang, Hu, Xueying, Xiao, Mengqing, He, Dong, Zhang, Yao, Jin, Yi, Hu, Yibo, Zhu, Yuxing, Gong, Lian, Wang, Zhanwang, Xiang, Liang, Zhu, Rongrong, Zhang, Yeyu, Cheng, Yaxin, Chen, Xingyu, Zhang, Shuihan, Peng, Yongbo, Cao, Ke
Format: Article
Language:English
Subjects:
Coliforms
Microbiota
Mucositis
Nanoparticles
Safety margins
Selenium
Self-assembly
Serum albumin
Transplantation
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Summary:Chemotherapy-associated intestinal mucositis is still one of the major challenges in the first-line clinical cancer treatment. Selenium element has shown health benefits on enteritis upon uptake in trace amounts; however, it was limited because of its narrow safety margin. In this work, a new form of Se@Albumin complex nanoparticles (Se@Albumin NPs) was developed by self-assembly of denatured human serum albumin and selenite salts. Se@Albumin NPs significantly improve intestinal mucositis induced with cisplatin (CDDP) in a mouse model via attenuating the level of intestinal oxidative stress, reducing intestinal permeability, and relieving gastric dysmotility. It is very interesting that the restoration of anti-inflammatory bacteria ( Bacteroidetes and Firmicutes ) and reduced abundance of proinflammatory bacteria ( Escherichia ) contributed to the reduction of intestinal mucositis by Se@Albumin NPs in mice. In addition, the fecal microbiota transplantation (FMT) with materials from Se@Albumin NP-treated mice significantly protected pseudo-aseptic mice from CDDP-induced intestinal mucositis. In conclusion, our findings showed that Se@Albumin NPs can significantly improve CDDP-induced intestinal mucositis, and its function may be directly mediated by gut microbiota regulation, which will provide new helpful information for clinical treatment.
ISSN:2040-3364
2040-3372
DOI:10.1039/D0NR07981B