3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

A new analogue of fluorinated pyrazoline (compound 1) has been synthesized via one-pot three-component reaction in a sealed-vessel reactor, Monowave 50. The structure of compound 1 has been established by spectroscopy analysis, including UV, FT-IR, HRMS, 1H and 13C NMR spectroscopy. Based on the in...

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Bibliographic Details
Published in:MolBank 2019-12, Vol.2019 (4), p.M1088
Main Authors: Zamri, Adel, Teruna, Hilwan Y., Wulansari, Sri, Herfindo, Noval, Frimayanti, Neni, Ikhtiarudin, Ihsan
Format: Article
Language:English
Subjects:
Binding sites
Caustic soda
Dengue fever
Ethanol
Hydrogen bonds
Infrared analysis
Infrared spectroscopy
Ligands
NMR spectroscopy
Pyrazole
Simulation
Viruses
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Summary:A new analogue of fluorinated pyrazoline (compound 1) has been synthesized via one-pot three-component reaction in a sealed-vessel reactor, Monowave 50. The structure of compound 1 has been established by spectroscopy analysis, including UV, FT-IR, HRMS, 1H and 13C NMR spectroscopy. Based on the in silico studies, this compound showed a good potential as an inhibitor for dengue virus type 2 (DEN2) NS2B/NS3 serine protease and can be used as a reference in the next design of an antidengue virus.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1088