Leptomeningeal Carcinomatosis in a Krukenberg Tumor Associated with Signet Ring Cell Gastric Cancer

Leptomeningeal carcinomatosis (LCM) is a rare complication of gastric cancer. It usually occurs late in advanced stage of disease and is sometimes misdiagnosed as toxicity of chemotherapeutic agents. Here we report a rare case of gastric cancer that developed LCM in follow-up. A 28-year-old woman wi...

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Bibliographic Details
Published in:Türk onkoloji dergisi 2016, Vol.31 (3)
Main Author: BASGOZ, Bilgin Bahadir
Format: Article
Language:English
Subjects:
Breast cancer
Cancer therapies
Case reports
Cellular biology
Chemotherapy
Diplopia
Gastric cancer
Lung cancer
Magnetic resonance imaging
Medical diagnosis
Medical prognosis
Metastasis
Nausea
Patients
Radiation therapy
Tumors
Vomiting
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Summary:Leptomeningeal carcinomatosis (LCM) is a rare complication of gastric cancer. It usually occurs late in advanced stage of disease and is sometimes misdiagnosed as toxicity of chemotherapeutic agents. Here we report a rare case of gastric cancer that developed LCM in follow-up. A 28-year-old woman with signet ring cell gastric cancer associated with Krukenberg tumor was admitted with persistent headache, nausea, vomiting, vertigo, and diplopia. Linear appearance of contrast enhancement in cerebellar fissures and around cranial nerves was seen in magnetic resonance imaging and cerebrospinal fluid was hypercellular with numerous carcinoma cells. LMC was confirmed and treated with intrathecal methotrexate and additional whole-brain irradiation. LCM is a rare complication, but occurs more often than expected and is often misdiagnosed. If patient who is being treated for gastric cancer presents with neurological symptoms, LCM should be kept in mind. Clinical improvement can be achieved with current treatment modalities, including radiotherapy, chemotherapy, or targeted molecules.
ISSN:1300-7467
2717-8978
DOI:10.5505/tjo.2016.1439