Solubility Enhancement of Atorvastatin Calcium by Solid Dispersion using Skimmed Milk Powder

[...]many new approaches have been addressed to improve the solubility and enhance the dissolution rates. [14] The advantages of SD method are simple method and its non toxicity. [...]no efforts has been done to prepare SD using skimmed milk. The absorbances of different dilutions were measured at 2...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2021-06, Vol.13 (6), p.365-368
Main Authors: Ashwini, A Bachhav, Satish, A Ahire, Anil, G Jadhav
Format: Article
Language:English
Subjects:
Bioavailability
Conflicts of interest
Drug dosages
Investigations
Permeability
Pharmaceuticals
Polymer solubility
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Summary:[...]many new approaches have been addressed to improve the solubility and enhance the dissolution rates. [14] The advantages of SD method are simple method and its non toxicity. [...]no efforts has been done to prepare SD using skimmed milk. The absorbances of different dilutions were measured at 246 nm using methanol as blank by UVVisible spectrophotometry Preparation of SD A SD containing Atorvastatin calcium with skimmed milk powder in varying ratios (Table1) were prepared by lyophilization [19]. The formulation was successful in significantly enhancing the solubility rate of Atorvastatin calcium. [...]the present methodology can be regarded as a commercially feasible technique for improving the solubility of Atorvastatin calcium with skimmed milk as carrier.
ISSN:0975-1459