Development of Hydrophilic Drug Encapsulation and Controlled Release Using a Modified Nanoprecipitation Method

The improvement of the loading content of hydrophilic drugs by polymer nanoparticles (NPs) recently has received increased attention from the field of controlled release. We developed a novel, simply modified, drop-wise nanoprecipitation method which separated hydrophilic drugs and polymers into aqu...

Full description

Saved in:
Bibliographic Details
Published in:Processes 2019-06, Vol.7 (6), p.331
Main Authors: Xu, Jiang, Chen, Yuyan, Jiang, Xizhi, Gui, Zhongzheng, Zhang, Lei
Format: Article
Language:English
Subjects:
Aqueous solutions
Ciprofloxacin
Controlled release
Dextran
Dextrans
Drug delivery
Efficiency
Glycolic acid
Hydrophilicity
Lactic acid
Methods
Morphology
Nanoparticles
Polyethylene glycol
Polylactide-co-glycolide
Polymers
Solvents
Spectrum analysis
Sustained release
Transmission electron microscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The improvement of the loading content of hydrophilic drugs by polymer nanoparticles (NPs) recently has received increased attention from the field of controlled release. We developed a novel, simply modified, drop-wise nanoprecipitation method which separated hydrophilic drugs and polymers into aqueous phase (continuous phase) and organic phase (dispersed phase), both individually and involving a mixing process. Using this method, we produced ciprofloxacin-loaded NPs by Poly (d,l-lactic acid)-Dextran (PLA-DEX) and Poly lactic acid-co-glycolic acid-Polyethylene glycol (PLGA-PEG) successfully, with a considerable drug-loading ability up to 27.2 wt% and an in vitro sustained release for up to six days. Drug content with NPs can be precisely tuned by changing the initial drug feed concentration of ciprofloxacin. These studies suggest that this modified nanoprecipitation method is a rapid, facile, and reproducible technique for making nano-scale drug delivery carriers with high drug-loading abilities
ISSN:2227-9717
2227-9717
DOI:10.3390/pr7060331