Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

• Published in: Processes 2019-11, Vol.7 (11), p.826
• Main Authors: Lett, Jayasingh Anita, Sagadevan, Suresh, Prabhakar, Joseph Joyce, Hamizi, Nor Aliya, Badruddin, Irfan Anjum, Johan, Mohd Rafie, Marlinda, Ab Rahman, Abdul Wahab, Yasmin, Yunus Khan, Tatagar Mohammad, Kamangar, Sarfaraz
• Format: Article
• Language: English
• Subjects: Antibiotics; Biocompatibility; Biofilms; Biomedical materials; Bone biomaterials; Bone grafts; Bone surgery; Buffer solutions; Calibration; Fatty acids; Fourier transforms; Health care; Hydroxyapatite; Leaching; Mechanical loading; Morphology; Nanoparticles; Nitrates; Orthopedics; Pathogens; Plastic surgery; Pore size; Reconstructive surgery; Spectrum analysis; Substitute bone; Surfactants; Transplants & implants; Vancomycin
• ISSN: 2227-9717; 2227-9717
• DOI: 10.3390/pr7110826

Infections after bone reconstructive surgery become an authentic therapeutic and economic issue when it comes to a modern health care system. In general; infected bone defects are regarded as contraindications for bone grafting. Since the pathogens develop a biofilm on the inner surface of the bone; local delivery of antibiotics becomes more important. The present work focuses on the synthesis of Mesoporous Hydroxyapatite (MPHAP) loaded with drug Vancomycin (Van) and to investigate its loading and leaching ability in phosphate buffer solution (PBS), to be used for post-operative infections. The effect of pore size on MPHAP was analyzed using different fatty acids as organic modifiers. The impacts of various fatty acids chain length on the morphology and pore size were studied. A simple impregnation technique with optimized conditions ensured a high antibiotic loading (up to 0.476 + 0.0135 mg/mL), with a complete in vitro release obtained within 50 h.