In Silico Tools and Phosphoproteomic Software Exclusives

Proteomics and phosphoproteomics have been emerging as new dimensions of omics. Phosphorylation has a profound impact on the biological functions and applications of proteins. It influences everything from intrinsic activity and extrinsic executions to cellular localization. This post-translational...

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Bibliographic Details
Published in:Processes 2019-12, Vol.7 (12), p.869
Main Authors: Paul, Piby, Muthu, Manikandan, Chilukuri, Yojitha, Haga, Steve W., Chun, Sechul, Oh, Jae-Wook
Format: Article
Language:English
Subjects:
Amino acids
Bioinformatics
Data analysis
Drug resistance
Energy costs
Genes
Genomes
Integrated software
Interdisciplinary aspects
Kinases
Localization
Mass spectrometry
Mathematical analysis
Mathematical programming
Medicine
Ontology
Peptides
Pharmacodynamics
Phosphorylation
Post-translation
Proteins
Proteomics
Scientific imaging
Software
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Summary:Proteomics and phosphoproteomics have been emerging as new dimensions of omics. Phosphorylation has a profound impact on the biological functions and applications of proteins. It influences everything from intrinsic activity and extrinsic executions to cellular localization. This post-translational modification has been subjected to detailed study and has been an object of analytical curiosity with the advent of faster instrumentation. The major strength of phosphoproteomic research lies in the fact that it gives an overall picture of the workforce of the cell. Phosphoproteomics gives deeper insights into understanding the mechanism behind development and progression of a disease. This review for the first time consolidates the list of existing bioinformatics tools developed for phosphoproteomics. The gap between development of bioinformatics tools and their implementation in clinical research is highlighted. The challenge facing progress is ideally believed to be the interdisciplinary arena this field of research is associated with. For meaningful solutions and deliverables, these tools need to be implemented in clinical studies for obtaining answers to pharmacodynamic questions, saving time, costs and energy. This review hopes to invoke some thought in this direction.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr7120869