Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films

Medical devices-related infections pose a great threat to patients and cause an increased morbidity and mortality. Herein, we prepare an antibacterial composite (TPU- x ) through blending medical grade thermoplastic polyurethane (TPU) and the complex (PL-DOSS) of ε -polylysine ( ε -PL) and docusate...

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Bibliographic Details
Published in:Chinese journal of polymer science 2021-08, Vol.39 (8), p.1020-1028
Main Authors: Liu, Xiao, Guo, Jian-Wei, Liu, Ya-Dong, Liu, Ming, Liu, Hui, Han, Miao-Miao, Ji, Sheng-Xiang
Format: Article
Language:English
Subjects:
Biocompatibility
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
E coli
Industrial Chemistry/Chemical Engineering
Mechanical properties
Nanoparticles
Polymer Sciences
Polyurethane resins
Urethane thermoplastic elastomers
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Summary:Medical devices-related infections pose a great threat to patients and cause an increased morbidity and mortality. Herein, we prepare an antibacterial composite (TPU- x ) through blending medical grade thermoplastic polyurethane (TPU) and the complex (PL-DOSS) of ε -polylysine ( ε -PL) and docusate sodium (DOSS). >99% reduction of colony forming unit (CFU) can be obtained in TPU- x composite films even at relatively low content of PL-DOSS, e.g. 0.13% for Methicillin resistant S. aureus (MRSA) and 0.5% for E. coli . The excellent antibacterial activity is mainly attributed to the formation of PL-DOSS nanoparticles that are uniformly dispersed in the TPU matrix with a size of ∼100 nm. TPU- x composite films exhibit long-term stability in saline and good biocompatibility, and retain mechanical properties of TPU.
ISSN:0256-7679
1439-6203
DOI:10.1007/s10118-021-2578-z